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Endocrine Abstracts

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ea0020p677 | Steroid Receptors | ECE2009

Effects of seocalcitol, TTNPB, phytol or their combinations on MNU-induced carcinogenesis of mammary gland and nuclear receptors expression in mammary tumours of female Sprague-Dawley rats

Ondkova Slavomira , Brtko Julius , Liska Jan , Jakubikova Lucia , Macejova Dana

1-methyl-1-nitrosourea (MNU) is a well characterized carcinogen that induces adenocarcinomas in rat mammary gland with high specifity. This model has proven to be of resemblance to human breast cancer. Synthetic analogs of vitamin D3 and retinoids have shown some promise as chemopreventive agents against chemically induced mammary gland carcinogenesis in rodents.Female Sprague-Dawley rats were given 50 mg/kg MNU i.p. on 46th and 52nd day of ag...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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